A. Publications Michael Walter

1. von Eckardstein A, Funke H, Walter M, Altland K, Benninghoven K, Assmann G. Structural analysis of apolipoprotein A-I variants. Amino acid substitutions are nonrandomly distributed throughout the apolipoprotein A-I primary structure. J Biol Chem 1990;265:8610-8617.

2. von Eckardstein A, Walter M, Benninghoven A, Assmann G. Site specific methionine sulfoxide formation is the structural basis of chromatographic heterogeneity in apolipoproteins A-I, C-II, and C-III. J Lipid Res 1991;32:1465-1476.

3. Walter M, Kerber S, Fechtrup C, Seedorf U, Breithardt G, Assmann G. Characterization of atherosclerosis in a patient with familial high density lipoprotein deficiency (Tangier disease). Atherosclerosis 1994;110:203-208.

4. Walter M, Gerdes U, Seedorf U, Assmann G. The high density lipoprotein- and apolipoprotein A-I-induced mobilization of cellular cholesterol is impaired in fibroblasts from Tangier disease subjects. Biochem Biophys Res Commun 1994;205:850-856.

5. Seedorf U, Walter M, Assmann G. Diagnosis of Smith-Lemli-Opitz-syndrome. [Letter] N Engl J Med 1994;330:1685-1687.

6. Berendes E, Walter M, Prien T, Assmann G, Lawin P. Digoxin-like immunoreactive substance in critically ill patients. [Letter] Anesthesiology 1994;80:1408-1409.

7. Walter M, Kerber S, Fechtrup C, Seedorf U, Breithardt G, Assmann G. Koronarangiographie und intravaskulÀre Ultraschalluntersuchung bei einem 60-jÀhrigen Patienten mit familiÀrer HDL-Defizienz (Tangier-Krankheit). Z f Kardiol 1994;83:381-385.

8. Tepel M, Heidenreich S, Zhiming Z, Walter M, Nofer J-R, Zidek W. Captopril inhibits the agonist-induced increase of cytosolic Ca2+ in glomerular mesangial cells. Kidney Internat 1994;46:696-702.

9. Walter M, Reinecke H, Nofer J-R, Seedorf U, Assmann G. HDL3 stimulates multiple signaling pathways in human skin fibroblasts. Arterioscler Thromb Vasc Biol 1995;15:1975-1986.

10. Nofer J-R, *Walter M, Kehrel B, Seedorf U, Assmann U. HDL3 activates phospholipase D in normal but not in glycoprotein IIb/IIIa-deficient platelets. Biochem Biophys Res Commun. 1995;207:148-154.

11. Tepel M, Schlotmann R, Barenbrock M, Kisters K, Torsten K, Spieker C, Walter M, Meyer C, Bretzel RG, Zidek W. Lymphocytic Na+-H+ exchange increases after an oral glucose challenge. Circ Res 1995;77:1024-1029.

12. Walter M, Reinecke H, Gerdes U, Nofer J-R, Höbbel G, Seedorf U, Assmann G. Defective regulation of phospatidylcholine-specific phospholipases C and D in a kindred with Tangier disease. J Clin Invest 1996;98:2315-2323.

13. Wronska-Nofer T, Laurman W, Nofer J-R, Seedorf U, Walter M. Carbon disulfide-induced modification and cytotoxicity of low-density. lipoproteins. Toxicol in Vitro 1996;10:423-429.

14. Tepel M, Heidenreich S, SchlĂŒter H, Beinlich A, Nofer J-R, Walter M, Assmann G, Zidek W. Diadenosine polyphosphates induce transplasma membrane calcium influx in cultured glomerular mesangial cells. Eur J Clin Invest 1996;26:1077-1084.

15. Nofer J-R, Tepel M, Kehrel B, Walter M, Seedorf U, Assmann G, Zidek W. High density lipoproteins enhance the Na+/H+ antiport in human platelets. Thromb Haemost 1996;75:635-641.

16. Nofer J-R, Tepel M, Kehrel B, Walter M, Seedorf U, Assmann G, Zidek W. Low density lipoproteins inhibit the Na+/H+ antiport in human platelets: a novel mechanism enhancing platelet activity in hypercholesterolemia. Circulation 1997;95:1370-1377.

17. Berendes E, *Walter M, Cullen P, Prien H, Schulte M, Horsthemke J, van Aken H, von Wild H, Scherer H. Brain natriuretic peptide secretion in patients with aneurysmal subarachnoid haemorrhage. Lancet 1997;349:245-249.

18. Nofer J-R, Tepel M, Walter M, Seedorf U, Assmann G, Zidek W. Phosphatidylcholine-specific phospholipase C regulates thapsigargin-induced calcium influx in human lymphocytes. J Biol Chem 1997;272:32861-32868.

19. Nofer J-R, *Walter M, Tepel M, Seedorf U, Assmann G. HDL3-mediated inhibition of thrombin-induced platelet aggregation and fibrinogen binding occurs via decreased production of phoshoinositide-derived second messengers 1,2-diacylglycerol and inositol-1,4,5-trisphosphate. Arterioscler Thromb Vasc Biol 1998; 18:861-869.

20. Walter M, Reinecke H, Heinrich J, Breithardt G, Assmann G. Factor V Leiden and thromboembolism. Circulation 1998;97:1426-1427.

21. von Eckardstein A, Chirazi A, LĂŒttmann S, Walter M, Kastelein JJP, Kuivenhoven JA, Geisel J, RĂ©al J, Miccoli R, Noseda G, Höbbel G, Assmann G. Plasmas and fibroblasts of Tangier disease patients are disturbed in transferring phospholipids onto apolipoprotein A-I. J Lipid Res 1998;39:987-998.

22. Rust S, Walter M, Funke H, et al. Assignment of Tangier disease to chromosome 9q31 by a graphical linkage exclusion strategy. Nature Genetics 1998;20:96-98.

23. Hoebbel G, Kannenberg F, Boknik P, Neumann J, Schmitz W, Assmann G, Walter M. Phosphatase inhibitors enhance cholesterol mass efflux. Circulation [Suppl] 1998;98:I-450.

24. Walter M, Berendes E, Claviez A, Suttorp M. Inappropriate secretion of natriuretic peptides in a patient with a cerebral tumor. JAMA 1999;282:27-28.

25. Nofer JR, Junker R, Walter M, Seedorf U, Assmann G, Zidek W, Tepel M. Phospholipase A2 is involved in thapsigargin-induced sodium influx in human lymphocytes. Arch Biochem Biophys 2000;374:213-221.

26. Walter M, Tepel M, Nau P, Nofer JR, Neusser M, Assmann G, Zidek W. Involvement of phospholipase D in capacitative calcium entry. FEBS Lett 2000;479:51-56.

27. Fobker M, Voss R, Reinecke H, Crone C, Assmann G, Walter M. Accumulation of cardiolipin and lysocardiolipin in fibroblasts from Tangier disease subjects. FEBS Lett 2001;500:157-162.

28. Nofer JR, Junker R, Pulawski E, Fobker M, Levkau B, von Eckardstein A, Seedorf U, Assmann G, Walter M. High density lipoproteins induce cell cycle entry in vascular smooth muscle cells via mitogen activated protein kinase-dependent pathway. Thromb Haemost 2001;85:730-5.

29. Nofer JR, Fobker M, Hobbel G, Voss R, Wolinska I, Tepel M, Zidek W, Junker R, Seedorf U, von Eckardstein A, Assmann G, Walter M. Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux. Biochemistry 2000;39:15199-207.

30. Utech M, Hobbel G, Rust S, Reinecke H, Assmann G, Walter M. Accumulation of RhoA, RhoB, RhoG, and Rac1 in fibroblasts from Tangier disease subjects suggests a regulatory role of Rho family proteins in cholesterol efflux. Biochem Biophys Res Commun 2001;280:229-36.

31. Berendes E, Van Aken H, Raufhake C, Schmidt C, Assmann G,
Walter M. Differential secretion of atrial and brain natriuretic peptide in critically ill patients. Anesth Analg 2001;93:676-82.

32. Berger TM, Kistler W, Berendes E, Raufhake C, Walter M. Hyponatremia in a pediatric stroke patient: SIADH or Cerebral Salt Wasting ? Crit.Care Med 2002;30:792-5.

33. Berendes E, Cullen P, Van Aken H, Zidek W, Erren M, Hubschen M, Weber T, Wirtz S, Tepel M, Walter M. Endogenous glycosides in critically ill patients. Crit Care Med. 2003;31:1331-7.

34. Berendes E, Schmidt C, van Aken H, Grosse Hartlage M, Wirtz S, Reinecke H, Rothenburger M, Scheld HH, SchlĂŒter B, Brodner G, Walter M. Reversible cardiac sympathectomy by high thoracic epidural anesthesia improves regional left ventricular function in patients undergoing coronary artery bypass grafting. A randomized trial. Arch. Surgery 2003;138:1283-1290.

35. Berendes E, Schmidt C, van Aken H, Raufhake C, Grosse Hartlage M, Rothenburger M, Scheld HH, Walter M. Atrial and brain natriuretic peptide in cardiac surgical procedures. Anesth Analg 2004;98:11-19.

36. Reinecke H, Trey T, Wellmann J, Heidrich J, Fobker M, Wichter T, Walter M, Breithardt G. Schaefer RM. Haemoglobin-related mortality in patients undergoing percutaneous coronary interventions. Eur Heart J. 2003;24:2142-2159.

37. Walter M, Forsyth NR, Wright W, Shay JW, Roth MG. The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway. J Biol Chem 2004;279:20866-20873.

38. Koldamova RP, Lefterov IM, Staufenbiel M, Wolfe D, Huang S, Glorioso JC, Walter M, Roth MG, Lazo JS. The LXR ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer’s disease. J Biol Chem. 2005;280:4079-4088.

39. Rudack C, Langer C, Stoll W, Rust S, Walter M. Vascular risk factors in sudden hearing loss. Thromb Haemost. 2006;95:454-61.

40. Meyer A, Bunzemeier H, Hausberg M, Walter M, Roeder N, Breithardt G, Reinecke H. Impact of different stages of chronic kidney disease on in-hospital costs in patients with coronary heart disease: the price of renal failure. Nephrology Dialysis Transplantation, in press

41. Weiß D, Bremer A, Stoll W, Walter M, Rudack C. Tympanotomy: a new treatment option for sudden hearing loss. Otology and Neurotology, in press.

42. Walter M., Interrelationships between HDL Metabolism and Aging. HDL, a fountain of youth or a companion of aging ? Arterioscler. Thromb Vasc. Biol , in press.


Submitted or in preparation:

43. Weiß D, Bremer A, Stoll W, Rudack C, Walter M. Synergistic effect of platelet integrin a2b1 expression and fibrinogen plasma levels on sudden hearing loss outcome. J. Thromb. Haemost.

44. Kannenberg F, Repa J, Roth M, Walter M. Cellular cholesterol homeostasis in telomerase-immortalized Tangier disease fibroblasts. J. Biol. Chem.

45. Rust S, Walter M. Clinical phenotype of combined autosomal recessive hypercholesterolemia and familial hypercholesterolemia. Case Report, Lancet.

46. Reunert J, Marquardt T, Walter M, Denecke J. A simple metod for therapeutic monitoring of farnesyl transferase inhibitors from peripheral blood cells.

47. Rust S, Jansen-Rust M, Marquardt T, Walter M. A novel mutation in the human ARH (autosomal recessive hypercholesterolemia) gene.

48. Scheel M, Reunert J, Denecke J, Marquardt T, Walter M. Apolipoprotein A-I and high density lipoprotein-mediated lipid efflux from Hutchinson-Gilford Progeria fibroblasts: possible implications for premature atherosclerosis.

49. Voss R, Reunert J, Scheel M, Marquardt T, Denecke J, Walter M. Gene profile of stress-inducible senescence is different from Progeria.


B. Other Publications

1. Arking DE, Becker DM, Yanek LR, Fallin D, Judge DP, Moy TF, Becker LC, Dietz HC. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 2003;72:1154-1161.

2. Assmann G & Schulte H. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Prospective Cardiovascular Munster study.
Am J Cardiol. 1992;70:733-737.

3. Baur JA, Zou Y, Shay JW, Wright WE. Telomere position effect in human cells. Science 2001;292:2075-2077.

4. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu C-P, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-352.

5. Bodzioch M, Orso E, Klucken J, Langmann T, Bottcher A, Diederich W, Drobnik W, Barlage S, Buchler C, Porsch-Ozcurumez M, Kaminski WE, Hahmann HW, Oette K, Rothe G, Aslanidis C, Lackner KJ, Schmitz G. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier
disease. Nat Genet. 1999; 22:347-351.

6. Brooks-Wilson A, Marcil M, Clee SM, et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet. 1999;22:336-345.

7. Cawthon RM, Smith KR, O’Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003;361:393-395.

8. Chang E, Harley CB. Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci 1995;92:11190-11194.

9. Ferrara A, Barrett-Connor E, Shan J. Total, LDL, and HDL cholesterol decrease with age in older men and women. The Rancho Bernardo Study 1984-1994. Circulation 1997;96:37-43.

10. Francis GA, Knopp RH, Oram JF. Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease. J Clin Invest. 1995;96:78-87.

11. Kuroo M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997;390:45-51.

12. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 2002;105:1541-1544.

13. Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS, White MA, Wright WE, Shay JW. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet 1999;21:115-118.

14. Nofer JR, Feuerborn R, Levkau B, Sokoll A, Seedorf U, Assmann G. Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux.
J Biol Chem. 2003; 278:53055-62.

15. Ouellette MM, McDaniel LD, Wright WE, Shay JW, Schultz RA. The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes. Hum Mol Genet 2000;9:403-411.

16. Robles SJ, Adami GR. Agents that cause DNA double strand breaks lead to p16-ink4a enrichment and to premature senescence of normal fibroblasts. Oncogene 1998;6: 1113-1123.

17. Rohrer L, Hersberger M, von Eckardstein A. High density lipoproteins in the intersection of diabetes mellitus, inflammation and cardiovascular disease. Curr Opin Lipidol 2004;15:269-278.

18. Samani NJ, Boultby R, Butler R, Thompson JR, Goodall AH. Telomere shortening in atherosclerosis. Lancet 2001;358:472-473.

19. Serfaty-Lacrosniere C, Civeira F, Lanzberg A, Isaia P, Berg J, Janus ED, Smith MP Jr, Pritchard PH, Frohlich J, Lees RS, et al. Homozygous Tangier disease and cardiovascular disease. Atherosclerosis. 1994;107:85-98.

20. Shay JW, Pereira-Smith OM, Wright WE. A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 1991;196:33–39.

21. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002;27:339-344.

22. Shay JW, Wright WE. Telomeres are double-strand DNA breaks hidden from DNA damage responses. Mol Cell 2004;14:420-421.

23. Wang MC, Bohmann D, Jasper H. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell 2003;5:811-816.

24. Wilson PWF, Anderson KM, Harris T, Kannel WB, Castelli WP. Determinants of change in total cholesterol and HDLC with age: the Framingham study. J Gerontol 1994;49:M252-M257.

25. Wright WE, Shay JW. Historical claims and current interpretations of replicative aging. Nat Biotechnol 2002; 20:682-688.